It is difficult to know exactly when the shift from gelatine to agar occurred. As often happens for scientific breakthroughs, agar was likely adopted incrementally alongside the use of other growth media. In 1913, for example, the first diagnosis of Serratia marcescens as a human pathogen was made by growing it on agar as well as on potatoes.
Most userland implementations of custom ReadableStream instances do not typically bother with all the ceremony required to correctly implement both default and BYOB read support in a single stream – and for good reason. It's difficult to get right and most of the time consuming code is typically going to fallback on the default read path. The example below shows what a "correct" implementation would need to do. It's big, complex, and error prone, and not a level of complexity that the typical developer really wants to have to deal with:，详情可参考同城约会
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A difficulty here, however, is that the TransformStreamDefaultController does not have a ready promise mechanism like Writers do; so the TransformStream implementation would need to implement a polling mechanism to periodically check when controller.desiredSize becomes positive again.