In 2009, PacBio published a paper expanding the principle into a full-blown sequencing technique. Once again, each nucleotide was labeled with a different colored fluorophore detectable by the ZMW to determine which base had been incorporated. The fluorophores were attached such that they would be cleaved off during the chemical reaction incorporating the base into the growing DNA strand; they would then diffuse out of the ZMW so that the next fluorophore could be detected. Sequencing took place on a chip with many wells simultaneously — a different type of parallelization where each well detected a single DNA molecule undergoing the same basic chemical reaction.
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Крупнейшая нефтяная компания мира задумалась об альтернативе для морских перевозок нефти14:56，推荐阅读下载安装 谷歌浏览器 开启极速安全的 上网之旅。获取更多信息
В первую очередь Гаврилов заявил, что, вопреки общепринятым убеждениям, именно одежда может скорректировать лишний вес у мужчин. Кроме того, модный эксперт упомянул миф о дорогих часах, которые являются главным элементом делового гардероба.，推荐阅读体育直播获取更多信息
The gaps between rationals is where we find irrational numbers. This comes with a lot of weird baggage explored in the previous article, but it also means that for any given irrational r, we have an inexhaustible supply of unexpectedly accurate rational approximations in the vicinity.，推荐阅读Line官方版本下载获取更多信息
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